Development of Bone
Bone is living tissue, a matrix of collagen, bolstered by calcium (primarily) and other minerals. Its very design allows for great strength and versatility. The human skeleton is light and mobile, and easily moved by muscle.

Bone tissue is continually remodeled by the body. Two bone cells, the similarly-named osteoblasts and osteoclasts are mainly responsible for the process.^2,3

Osteoblasts synthesize and secrete osteoid, the organic compound of the bony matrix. Osteoblasts also help “mineralize” the organic matrix of bone, bringing calcium, magnesium, and other minerals into the structure. Osteoclasts, on the other hand, are responsible for the resorption of the bone matrix and the release of calcium and phosphate from bone.^2,3

In an ideal balance, bone tissue being replaced equals reabsorbed bone. Three major factors that affect this are:

• Biochemical: includes hormones, growth factors and cytokines that modulate the bone-building process
• Mechanical: includes weight bearing stress, which fuels the generation of new bone tissue and mineral replacement
• Nutritional: includes the proper intake of calcium, magnesium and vitamin D to help build the bone matrix²

Any imbalance in this process can be a challenge for bone health.^3-5 Supplements containing calcium and other bone-building nutrients can support healthy bones and bone structure.^†3

Conclusion
Proper calcium intake early in life can provide the greatest benefits to overall bone health.^† However, most Americans above the age of 9 do not get the calcium they need through diet alone. Supplementation with an readily absorbable calcium that combines magnesium and vitamin D can help fill the nutritional gaps often present in the average diet.^†29

• 070067;16 fl. oz (437 ml)

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